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KMID : 0043320010240040338
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Archives of Pharmacal Research
2001 Volume.24 No. 4 p.338 ~ p.341
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Circadian Changes in Pharmacokinetics of Sulfamethoxazole Administered Orally to Rabbits
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Choi JS
Jung EJ
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Abstract
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Circadian variations of sulfamethoxazole pharmacokinetics were studied after a single oral administration of sulfamethoxazole, 50 mg/kg, to rabbits at 09:00 (a.m.) and 22 :00 (p .m.). The profiles of plasma sulfamethoxazole concentration showed from 6h to 24 h significant statistical difference (p<0.05) between 09:00 and 22:00. The half-life (t1/2) was significantly shorter in the morning (11.2 +- 3.2 h) when compared to the nighttime (15.4 ±3.5h) (p< 0.05). The AUC was significantly decreased in the morning (1325 ±264mcg/ml·h) than that in the nighttime (2059 ±379mcg/ml. H) (p<0.05). Total body clearance (CL,) was significantly higher when sulfamethoxazole was given in the morning (6.65 ±0.23 ml/min) versus in the nighttime (4.28 ±0.20 ml/min) (p<0.05).
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